The reference site for Thioridazine

Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.

WHAT IS Thioridazine?

Thioridazine is in a class of drugs called phenothiazines, and works by changing the actions of chemicals in the brain.

This medication is used to treat psychotic disorders such as schizophrenia and depression. It helps to think more clearly, feel less nervous, and take part in everyday life. It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others, as well as help decrease the negative thoughts and hallucinations.

Thioridazine is generally reserved for people who do not respond to other drugs or who cannot take other drugs due to specific side effects.

Brand Name(s): Mellaril; Mellaril-S
CAS nº: 50-52-2
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Product Info

The sections below will provide you with more specific information and guidelines related to thioridazine and its correct use. Please read them carefully.

FDA Information

Thioridazine was approved by the U.S. FDA in 1959.

However, the manufacturer (Novartis/Sandoz/Wander) of the brands of thioridazine – Mellaril® in the US and Canada and Melleril® in Europe – discontinued the drug worldwide in June 2005.

Nevertheless, thioridazine may still be available from other manufacturers as a generic drug with the precaution that it is used only in psychotic patients refractory to other forms of drug treatment.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Thioridazine is in a class of drugs called phenothiazines, and works by changing the actions of chemicals in the brain.

This medication is used to treat psychotic disorders such as schizophrenia and depression. It helps to think more clearly, feel less nervous, and take part in everyday life. It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others, as well as help decrease the negative thoughts and hallucinations.

Thioridazine is generally reserved for people who do not respond to other drugs or who cannot take other drugs due to specific side effects.

Other uses for this medicine

Thioridazine is also sometimes used for night-time sedation.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Thioridazine comes as a tablet, liquid suspension, and liquid concentrate to be taken orally. It is usually taken two to four times a day.

Take thioridazine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Your doctor may want to monitor your heartbeats and obtain a blood sample before starting and periodically during treatment with thioridazine.

Each dose should be taken with a full glass of water, and either with or without food.

Shake the suspension (Mellaril-S®) well before using it.

To ensure that you get a correct dose, measure the liquid forms of thioridazine with a dropper or a special dose-measuring spoon or cup, and not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

The liquid concentrate can be mixed with 2 to 4 ounces of water or a suitable juice. Each dose should be mixed just prior to taking.

Do not let the liquid concentrate touch your skin or clothes.

Throw away any discolored liquid.

Do not stop taking thioridazine without first talking to your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time.

What special precautions should I follow?

BEFORE TAKING THIORIDAZINE:

Do not take thioridazine if you have any of the following conditions or a history of these conditions: heart disease, an irregular heartbeat or a history of irregular heartbeats, a history of prolonged QT intervals, a family history of congenital long QT syndrome, or other heartbeat disturbances. These conditions may increase the risk of irregular heartbeats, heart attack, and death while taking thioridazine.

Moreover, tell your doctor if you have a bone marrow disease, glaucoma, seizures, Parkinson’s disease, an enlarged prostate or difficulty urinating, liver disease, or kidney disease. You may not be able to take thioridazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above

Do not take thioridazine with any of the following drugs: psychiatric medications such as fluoxetine (Prozac®), paroxetine (Paxil®, Paxil CR®), and fluvoxamine (Luvox®); or blood pressure medications such as pindolol (Visken®) or propranolol (Inderal®, Inderal LA®, others). Taken with any of these drugs, thioridazine may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with thioridazine and cause heart problems, therefore please talk to your doctor or pharmacist before taking any other prescription or over-the-counter medications.

Thioridazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if thioridazine is taken with alcohol or any of these medications. Talk to your doctor before taking thioridazine in combination with alcohol or any other medicines.

It is not known whether thioridazine will harm an unborn baby. Do not take thioridazine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Additionally, it is not known whether thioridazine passes into breast milk. Do not take thioridazine without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from thioridazine. Your doctor may prescribe a lower dose of this medication or you may require special monitoring during treatment.

Use cautiously when driving, operating machinery, or performing other hazardous activities as this medication may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Avoid prolonged exposure to sunlight. Thioridazine may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

It is strongly advised never to take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking thioridazine and seek emergency medical treatment or contact your doctor immediately:

an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives)
uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs
fever
muscle rigidity
muscle spasms of the face or neck
sweating
irregular pulse
fast or irregular heartbeats
severe restlessness or tremor
severe drowsiness
blurred vision
dizziness or fainting
a rash

Other, less serious side effects may be more likely to occur. Continue to take thioridazine and talk to your doctor if you experience:

dry mouth, stuffy nose
constipation
mild restlessness, drowsiness, or tremor
decreased sex drive
increased appetite
difficult urination or dark urine
menstrual irregularities or swollen breasts

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Furthermore, the liquid form should also be kept in a light-resistant container.

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services immediately on 911.

Symptoms of overdose may include:

uncontrollable movements
agitation
seizures
severe dizziness or fainting
coma
very deep sleep
irregular heartbeats
high or low body temperature

Product Images

PICTURES OF THIORIDAZINE PILLS

Below you will find images and specific information on the principal types of thioridazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: THIORIDAZINE
Strength(s): 10 MG
Imprint: 10 | M 54
Manufacturer: MYLAN

Name: THIORIDAZINE
Strength(s): 10 MG
Imprint: 30 GG
Manufacturer: SANDOZ

Name: THIORIDAZINE
Strength(s): 15 MG
Imprint: GG 31 | 15
Manufacturer: SANDOZ

Name: MELLARIL®
Strength(s): 15 MG
Imprint: 78-8
Manufacturer: NOVARTIS

Name: THIORIDAZINE
Strength(s): 25 MG
Imprint: MP 14
Manufacturer: URL / MUTUAL PHARMACEUTICALS

Name: THIORIDAZINE
Strength(s): 25 MG
Imprint: M 58 | 25
Manufacturer: MYLAN

Name: THIORIDAZINE
Strength(s): 25 MG
Imprint: 4642
Manufacturer: RUGBY LABS.

Name: THIORIDAZINE
Strength(s): 25 MG
Imprint: 25 | GG 32
Manufacturer: SANDOZ

Name: THIORIDAZINE
Strength(s): 50 MG
Imprint: MP 17
Manufacturer: URL / MUTUAL PHARMACEUTICALS

Name: THIORIDAZINE
Strength(s): 50 MG
Imprint: M 59 | 50
Manufacturer: MYLAN

Name: THIORIDAZINE
Strength(s): 50 MG
Imprint: 4643
Manufacturer: RUGBY LABS.

Name: THIORIDAZINE
Strength(s): 50 MG
Imprint: 50 | GG 33
Manufacturer: SANDOZ

Name: THIORIDAZINE
Strength(s): 100 MG
Imprint: MP 160
Manufacturer: URL / MUTUAL PHARMACEUTICALS

Name: THIORIDAZINE
Strength(s): 100 MG
Imprint: M 61 | 100
Manufacturer: MYLAN

Name: THIORIDAZINE
Strength(s): 100 MG
Imprint: 100 | GG 34
Manufacturer: SANDOZ

Name: THIORIDAZINE
Strength(s): 100 MG
Imprint: 4644
Manufacturer: RUGBY

 Name: MELLARIL®
Strength(s): 100 MG
Imprint: MELLARIL 100
Manufacturer: NOVARTIS

Name: THIORIDAZINE
Strength(s): 150 MG
Imprint: GG 35
Manufacturer: SANDOZ

Name: THIORIDAZINE
Strength(s): 200 MG
Imprint: GG 36
Manufacturer: SANDOZ

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